The dry niosomes disperses or dissolves to form a suspension of multilamellar niosomes. Systemic and local side effects are successfully reduced due to the reduction in the total amount of the drug. Then the open end of the glass bottle is covered with a lid to prevent the loss of solvent from it and then it is warmed over water bath at 60-70°C for about 5 min until the surfactant mixture is dissolved completely. The released action of niosomes is applicable to the drugs with low therapeutic index and having low water solubility since these conditions for the drug can be maintained in the circulation through the encapsulation of niosome. Drugs having biological half life of 1hr or less are difficult to formulate as controlled release formulation. The drugs can be physically trapped into the core of block copolymer micelles and transported at concentrations that can go farther their intrinsic water- solubility. Advantages of hybrid optics In glass-polymer hybrids, a fairly thin layer of aspherized optical polymer is added to a conventional spherical glass lens. The multilamellar vesicles are frozen .After freezing it is thawed 3 times and later sonicated. * “Smart” polymer : polymer can response to external stimulation such as temperature, electricity and light. 1.4 Advantages of Polymer Material for Mass Production Now-a-days there is a very little gap between use of metals and polymers. These carriers (liposomes) are biologically inert in nature, lacking in any antigenic, pyrogenic or allergic reactions .The components of carriers can be used as the component of biological membrane. These dosage forms include tablets, patches, tapes, films, semisolids and powders. When these formulations are developed, the goal is to obtain the systems with optimized drug loading and release properties, long shelf-life and reduced toxicity. Encouragingly, these barriers that impede the efficacy of anti-PD therapy can be potentially addressed by nanosized drug delivery systems (NDDS) [37,38].NDDS can reduce the “on target but off tumor” effect of anti-PD drugs by delivering them specifically into tumors, taking advantages of their passive or active targeting capability after proper modification and engineering Once drug is administered it cannot be removed if an undesirable action is precipitated or if the drug is no longer needed. Protections from the first pass metabolism, gastro intestinal tract degradation and maximizing availability with minimum dose. When in need of a custom-machined component for a project, choosing a metallic material may be the instinctive consideration to the design engineer. The second approach uses carriers such as liposomes, niosomes, microspheres, nano particles, antibodies, cellular carriers (erythrocytes and lymphocytes) and macromolecules to direct drug to its site of action. Can be done in small labs whereas metals require large workshops to huge industries FLEXIBLE ADVANTAGES OF APPLICATIONS OF BIODEGRADABLE POLYMERS • Polymer system for gene therapy. Since this Technology is quite different from innovator so during stability study need to pack product in different “material of construction” and observe which combination is best suited for this product. Polymer use advantages and disadvantages and their respective impacts on society (Science and Society) Polymers scientifically explained: What are polymers? From simple essay plans, through to full dissertations, you can guarantee we have a service perfectly matched to your needs. Phone: 23-456-789 Fax: 098-765-432 123, New Lenox Chicago, IL 60606 Polymer are widely used in structural components in automobiles due to some advantages they offer, which are not found in other material. The niosomal delivery of this drug to mice bearing S-180 tumor lead to the growth in their life span. Then this suspension is vortexed. Polymer parts do not require post-treatment finishing efforts, unlike metal. Strength and hardness is low compared with ceramics and metals. 1.4 Advantages of Polymer Material for Mass Production Now-a-days there is a very little gap between use of metals and polymers. addition polymers – level 8 chemistry option c. advantages of polymers pdf download viewsicex org. Some of their therapeutic applications are discussed below. In a clean and dry wide mouthed glass vial of 5.0 ml capacity exactly weighed amounts of surfactant, lipid and drug are taken and alcohol (0.5 ml) is added to it. Niosomes, similar to liposomes, assume spherical shape. Do watch our videos "Polymers Part 1 … ii) Chemical resistance, impact resistance, and abrasion resistance. The first approach involves chemical modification of the parent compound to a derivative which is activated only at the target site. Polymers are large molecules that are formed by joining two smaller molecules called the monomers. POLYMERS for CDDS--class slides (1).pdf - Polymers Introduction classification properties advantages and application of polymers in the formulation of. The uptake of niosomes by the cells is by circulating serum factors known as opsonin.This factor which mark them for clearance. As new polymers went into the development process, the plastics advantages and disadvantages required constant review to avoid detrimental environmental impacts. There are two types of polymers: Natural polymers : They are those found in nature. Cholesterol and surfactant in the ratio 1:1 are dissolved in a mixture of ether and chloroform. The major advantages of Niosomes as drug carriers includes: Based on the method used for the production and composition of bilayer, niosomes show a wide variation in their properties. Selection of Primary Packaging material (precaution to take) Don’t follow 100% innovator’s primary packaging material of construction. It is novel technique for the one step preparation of liposomes and niosomes. ble polymers offer a safe passage for drug delivery due to their well engineered molecular architecture according to the transitions in the underlying mechanisms of the biological process. • The polymer under heating it can convert one stare to anther state and after cooling it can again convert its original state. Our academic experts are ready and waiting to assist with any writing project you may have. 1. The dispersion is mixed for 15 seconds with high shear homogenizer. Niosomes or non-ionic surfactant vesicles are microscopic lamellar structures formed on admixture of non-ionic surfactant of the alkyl, dialkyl polyglycerol ether class and cholesterol with the subsequent hydration in the aqueous media (3). 3. These approaches generally were not concentrated to achieve site specific or targeted delivery such as getting a cytotoxic drug to cancerous tissue while reserving other normal, though equally sensitive tissue. Subject: Novel Drug Delivery Systems Course: Pharmaceutical Sciences Improved patient compliance. This preview shows page 1 - 9 out of 44 pages. The vehicles polymer employed should be sterile, hydrogen free, non irritating, biocompatible and biodegradable into non toxic compounds within an appropriate time preferably close to duration of action. For example, natural rubber is prone to degrade in the presence of oxygen, ozone and light, although additives can improve the situation. March 25, 2019. Briefly, you can design synthetic polymers for specific uses. of controlled release drug delivery systems. There is a swift progress in the NDDS, so as to overpower the restrictions of conventional drug delivery. Advantages of polymer assisted solution phase essay for inauguration speech video best knee prosthesis Child psychology can explain the creative process defines the general guidelines in chapter is to emphasize that any given level of that issue research an authority the ontario institute for human economic development institute, washington, dc: The brookings institution. This procedure is followed by sonication. Aggregation or fusion of vesicles as a function of temperature was determined as the changes in vesicle diameter by laser light scattering method. Basis of this method is submerged jet principle. Coacervation phase separation method: This method is widely adopted to formulate proniosomal gel. advantages of polymers by on prezi. Copolymers present advantages not usually seen in homopolymers. Future Market Insights’ recent research report titled “Advantages Of Polymers In Construction Market: Global Industry Analysis (2012-2016) and Opportunity Assessment (2017-2026)” offers a comprehensive analysis on the global Advantages Of Polymers In Constructions market by covering all valuable aspects associated with the production, application and sales of these materials. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences. The drug is protected from first pass metabolism and GI degradation. Monoclonal antibodies may sometimes can cause unwanted antigen – antibody reaction which leads to serious consequences. This video contains Multiple Choice Questions and Answers of "Polymers" topic of Novel Drug Delivery Systems. * High tensile strength compared to its weight : some polymers can be as strong as metal and somehow cheaper. The bubbling unit consists of round-bottomed flask with three necks positioned in water bath to control the temperature. The objective of the drug targeting is to aim at a desired pharmacological response at a selected site without objectionable interactions at other sites. Drug targeting is the delivery of drugs to the receptors or any other specificied part of the body to which one desires to deliver the drug. This results to a thin film on the wall of the round bottom flask. Changing vesicle composition, size, lamellarity, tapped volume, surface charge and concentration can control the vesicle characteristics. The organic phase is removed at 40°C under low pressure. Reduced rate of rise of drug concentration in blood. Modulus of elasticity or stiffness is generally low in polymers. shape memory polymers. The basic objective of sustained drug release is to achieve more effective therapies by eliminating potential for both under and overdosing. Polymer materials handle … Polymers are more resistant to chemicals than their metal counterparts. After preparing the niosomal dispersion, unentrapped drug is separated by either the method of dialysis [15] entrifugation [17-18] or gel filtration [19] as described above and the drug remained entrapped in niosomes is determined by the complete vesicle disruption using 50% n-propanol or 0.1% Triton X-100.The resultant solution is analysed by the appropriate assay method for the drug. The antimonials at high concentration will affect and damage heart, liver and kidney. Improved treatment of chronic illness where symptoms break through occurs when the plasma level of the drug falls below the MEC. There are many additive options available and each one offers a specific improvement to the polymer’s functionality or stability. 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