My dog is still having tremors 5 months after taking Simparica. No simparica for them either! He is back to his old self now but we will never give him this medication again. Reading all these similar cases cant figure out how the hell this crap is still being prescribed. I took my dog to the vet today and she received fluids and gabapentin. Since the weather was turning cold, I stopped giving her the Simparica until spring. Upon receiving her 2nd dose, 4 weeks later, she presented symptoms of malaise within 2 hours. My dog has had 3 seizures in the past from wearing a flea collar. It has been 5 days since she had the 3 seizures in 24 hours. Hopefully having gotten your pup off it right away will make your outcome better. Heres what you need to know about why cats purr and what your cat may be telling you when her motor is running. Hi, my dog is having these same issues right now and Im dying. Reading all of these comments I too think it is the drug that has caused his body to be toxic for him. So I did. Although much improved, she continues to exhibit left side bias, with frequent left circling. How is your cockapoo doing now? About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. He is fully housebroken and just had a running stool accident in the house. Do you have a homeopathic vet in your area? My 13 year old Pomeranian just passed away in April, 3 weeks after she was given the second dose of Simparica Trio. Started in February and within a couple of weeks ears started twitching. The vet came and picked her up and cut her opened and said and told me she could anything wrong with her so it was either she was poisoned or it was a neurological disorder. Still waiting on the vet and waiting to talk to ASPCA poison control. The ataxia, peeing himself, tremors started again. We talked with Zoetis (the manufacturer of Simparica) after the FDA's announcement to get some concrete numbers on the frequency of these adverse reactions. But today, after he ate dinner and drank water, it all came back up. If it was due to the Simparica, then it would expected to be resolved within a day or two. I rescued a dog that had a light case of heartworms. Bravecto 18. She had a beautiful coat of fur. Other specific monitoring or routine testing while your pet is on this medication may be recommended by your veterinarian depending on your pet's individual needs. Im going to another vet and discontinuing simparica. I will never give this again! Bella is a very anxious dog and is my husbands shadow. Our dog had her first dose June 1st 2022 - diarrhea, scratching, excessive thirst. My vet seems skeptical that this is related to simparica but it seems clear to me, although I realize that anecdotal cases don't prove it. He had to be put to sleep and Im devastated. Simparica has been approved by the FDA to treat and prevent flea and tick infestations. If it has been a long period of time since the last dose was given, you may see fleas temporarily during the missed time. Has anyones dog stopped having seizures when the medication wore off or is this going to be a permanent issue possibly getting worse? Will NEVER give this to my dog again. Never happened before. Coincidence? This medication is generally well tolerated in most pets. No appetite, not like Charlie. Product Details: Simparica Trio Chewables for dogs. She had terrible vomiting and diarrhea for a week and also weakness and staggering three weeks later. The only thought in my head was to get home and give it to my puppy who has had few fleas, but many itching problems. (toy aussie & corgi). Advised I could call Simparica for reimbursement or to report side effects. Product (Reports), Deaths/%, Seizures/% Nexgard 18. I am convinced this medicine is HORRIBLE and is causing this. Discuss Simparica chewable treats with your veterinarian when looking for a safe, effective way to arm your dog against biting parasites and the diseases they carry. Note: Lotilaner (Credelio) AE reports were not available via FOIA due to the newness of this drug Spinosad (Comfortis) AE reports not available at time of analysis Thankfully there have been no other side effects. After spending the day at the ER Vet where they did bloodwork and several x-rays all coming back normal, they sent her home with Keppra. Thanks Michelle! Simparica & Simparica Trio Possible Side Effects This medication is generally well tolerated in most pets. Does this sound familiar to anyone? After realizing that the only thing that we did differently was to give him his first dose of Simperica, my wife began research and came across this conversation. My miniature Dash hound did not pull out. 32,374 Adverse Event Reports in Dogs. Never had them ever and she's only 3 1/2 yrs old. After seeing his condition worsen, that night we took him to an after hours urgent care. Vet said if she vomits bring her in. This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. I feel so dumb for taking him off of something that we had no problems with and it worked fine, just to try something new that he didn't need. I will never use this stuff again and will tell anyone I see buying it or using it my story and yours too. Product Information: Simparica Trio (sarolaner, moxidectin, and pyrantel) Chewables are a safe monthly chewable for dogs that prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworms and . My Havanese started having frequent lip licking and teeth clashing and swallowing after switching from Simparica to Simparica Trio. We administered the first dose on Wednesday June 1st to our 9 year old bouvier flanders. I hope there will be a class action lawsuit but most importantly that the word get out to stop this medication from harming another life. Did you ever do an MRI or spinal tap? However, doing nothing is better than giving her the Simparica. Hi Laura, How is you pup doing one after getting off simparica? They don't really have an answer for why this happens at all, or why some dogs get better and some don't. She has good days and bad days but she is far from the dog she use to be. But anyways - the other night , his feet collapsed from under him & he fainted . Find the Right Simparica for your dog. She is lethargic and doesnt want to eat. By Sunday he is having liquid diarrhea! Im certain that its the simparica. We gave our one year old Simparica tonight and he started having trimmers that lasted on and off for about 30 minutes. (Ours never did, she died 4 months later.) If she had just taken it they could give her Charcoal. Dogs with existing heartworm infections should be treated to remove the adult heartworms before going back on this medication. He seems to be out of sorts, staring into space, getting freaked out when he can't see me (I thought he was losing his eyesight). I've beaten myself up so much giving her this drug, I felt I could trust the vet and the drug company but we obviously cant and it's all about making more money. If your dog ate two doses of Simparica Trio, he might experience minor tremor depending on the size of the dog. My aunt gave her 5.5-kg, 13-year-old female shih tzu the first dose of Simparica and she has never been the same as she shows symptoms of cardiopulmonary illness: lethargy, loss of appetite, vomit, coughing, seizure and excessive drinking. Are there any side effects to Simparica Trio? Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). This simple-to-give oral monthly treatment protects dogs against heartworm disease as well as against ticks and fleas and intestinal worms like roundworms and hookworms. I am starting to get scared they are both 80 lbs and the other dog is. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. He is otherwise normal and healthy. I gave my six-year-old dog SIM perica because the combo guard was on back order. Called his vet and they gave no information. By Tuesday evening symptoms came back worse. Side effects are rare and may include: Neurologic side effects have been seen after using medications in this class of drugs. Next day she seemed different, standing slightly strangely. She will never have this again, I can assure you! When we took him to the emergency vet they waved us off when we brought in the package, inquiring if it was the cause. Other signs may include: Lethargy Loss of appetite My 3 year old dog has been on Simparica since he was a puppy, with no side effects that I've noticed. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. Pyrantel only treats parasites found in the gastrointestinal tract because it does not absorb well into the bloodstream. Her last dose of Simparica Trio was given to her on October 1, 2021. He lays on his bed tucked far in the corner. He woke up and seemed much brighter. Hi, Im wondering whats going on with your dog now? He was a dog you could pick up anytime and he was good as gold. She seems to have aged five years since T-Day. only 7 yrs old and I still considered a puppy b/c of how active he was, we are on 8 days now of the lethargic not eating, goopy eyes - Dr says he has hyernaited disc but I have yet to see the xrays to confirm - blood work came back normail. Thanks all for sharing your experiences. Now her dog is very sick and she has to take the dog to the vet every day in the past week. I thought maybe my dog had a bladder infection or got into something that upset her gut. She said to watch for drainage. Im wondering if anyone else has seen these types of symptoms. So, again, tears in my heart, THANK YOU ALL SO MUCH for your generous information. Then I saw this and realized. Same as you describe. If anyone has suggestions or knows how else I can help my little guy please let me know. Training your dog to follow basic commands builds a positive relationship with her and helps ensure her safety. It could be a coincidence but seems too coincidental. I to also gave my best friend Simparica as recommended by the vet. Simparica uses Sarolaner, which works by overstimulating the nervous system of the pests. A day and a half after her 3rd dose of Simparica she had a really bad gran mal seizure and we though she was going to die. This time he just kept collapsing, bloated appearing, vomit, and diarrhea, and hiding with his face down and nose in carpet. Was prescribed Simparica Trio for my Catahula dog with no medical issues. Side effects with Simparica are not common. He walked outside peed then tried to come back in the house but his legs gave out . I have ordered what I normally use and will throw this in the trash! Vet trip and meds $400! And yeah he ate today 4 chicken breast and appeared to want it even better. Our dog has not been given another dose. All other pets in the home must also be treated with a flea control product for a minimum of 30 days prior to the report. They had no clue what had happened so again we took him to the er and he checked out fine. We just brought him home from hospital today. Within 24 hours, he would not leave my bedroom, slept all day, no appetite. He had a problem with severe biting a few months back and Vet said he most likely allergic to fleas (bites). Coton de Tulear. I hope the best for you and dog, I know its a tough time. She was ok for awhile, then she had a seizure and started throwing up all over the house. Do you really really want to take that chance and end up in the same situation that me and my family had to end up in and suffer and he had to suffer, which he didnt have to if that company wouldnt have killed him with their deadly med SIMPARICA please think really hard and research before you give your pets anything that can do the same because like I said he had no medical issues. Since she is young, the vet started us with Keppra. Pyrantel Pamoate got its approval for the first time by the FDA for the purpose in 1977. CDC warns tick-borne illnesses have nearly doubled since 2004 No diarrhea or vomiting or seizures. There is a petition in Australia to have this drug banned through change.org, which I've signed. I feel horrible for listening to the vet without researching this on my own. He looked like he was having a seizure. Again he has diarrhea and this month he seems agitated or nervous. His temp was high and white blood cells elevated. I made some chicken and rice. Simparica is available by prescription only, so discuss any history your dog has of seizure disorders with your veterinarian when determining the best flea and tick treatment for your pet. I am sure simparica caused a fatal seizure in my boxer. I gave my dog simparica at 10:15am. Same thing has happened to my 5 month old puppy after taking simparica. Neurological reactions: In rare cases, dogs may exhibit tremors, ataxia (loss of coordination), or seizures as a side effect of the medication. She started it on 7/22. He has trouble raising his leg to urinate. No problem eating. The Simparica chewable is a poor choice for dogs with a history of prior seizures. He seemed to get a little better over the next week until he woke at 5am vomiting and having diarrhea and very lethargic. Hearing 35-40 to leave systems. Hi, Im having similar issues. No this puppy hasnt had seizures and I came to this forum to see other problems with this medicine. She spent 4 nights at the University of Auburn emergency room and vet clinic. Pyrantel only treats parasites found in the gastrointestinal tract because it does not absorb well into the bloodstream. Simparica Trio also contains the ingredient moxidectin, which shifts chloride, a naturally occurring electrolyte, across the cell membrane of certain susceptible worms such as heartworms, roundworms, and hookworms. If she comes out of this I will return to heartworm pills and topical flea and tick meds. Did you ever get to the bottom of redness in eyes? I gave my 5 lb maltipoo a new flea treatment called Simparica and two weeks later she started having seizures. Is Simparica only available with a prescription? She had the treatment yesterday and seemed ok. We have been gradually increasing the dose but it hasnt helped. but wasnt allowed in with him. She hasn't had any of the diarrhea or eating issues, but has had one of her eyes that gets red and the inner eyelid partially covers her pupil. This was the first time she was given this drug and will be the last. I just wish I could find a vet who honestly loves my animals as much as I do. We tried stopping the simparica. Like other oral treatments, Simparicaworks by entering a dogs bloodstream immediately after ingestion. Today really soft stool (not diarrhea but close). Any believers out there please say a prayer for our pup as I will for the people on this thread. The day after administering drug he had two incapacitating seizures. I just wanted them gone and for him to feel better. It is really eye-opening to see everyone's experiences. One common alternative is to give Heartgard for heartworms and intestinal parasites along with Bravecto to prevent fleas and ticks, but there are other choices out there. My little Billy Boy had his first visit to the vet and they gave him Simparica Trio. They got him to eat a little the next morning and sent him home. The active ingredient of Simparica, sarolaner, belongs to a newer class of flea and tick preventatives called isoxazolines. We gave our 3.5 month old Aussie pup a dose of Simparica today (vet's prescription), and I did not see the warnings about giving it to dogs under 6 months. I'm so glad I found this forum, it confirmed my instincts that this drug is very harmful. Shes not the carefree setter she was prior to this medication. Started giving my dogs Simparica Trio 5 months ago didn't put together the changes in the one dogs personality until today within a couple of weeks she would all of a sudden go from a loving dog to attacking the other dog it is getting worse. It kills heartworm larvae by causing paralysis that leads to the death of the parasite. My dog is having seizures. She has been very unpredictable and snapping at people but this is improving. He had it once before with no issues. I notified my vet and Zoetis, the company that makes this drug. I had always thought how can something so lethal to fleas an ticks be safe to ingest? Been also very lethargic not wanting to get out of bed. Did the tremors ever stop? They kindly asked that we schedule an immediate check and diagnostic testing at our local vet. Sound familiar? Has anyone else experienced this? We took him to a emergency Vet Hospital that pin pointed Simparica Trio as the main facture that triggered his controlled seizure episodes in having constant all day tremors & seizures hurting him to the point of making the decision to put him down or have him continue with the pain until it killed him. I'm so sorry. Two months no flare up no more scabs and loosing hair. Simparica Trio is considered safe for dogs as young as eight weeks old who weigh at least 2.8 pounds. I advise all pet owners to know the side effects. Hope your dog is doing well .my dog had clear neurological changes after taking Simparica trio .his tounge just hangs out of his mouth now and that was never the case prior to Simparica,also has tremors and shakes he never previously experienced.also major weight gain even though no increase in diet .i decided to take my pet off of simparico even though the vet strongly engouraged we remain on it even though i explained the symptoms and changes I noticed in my pet ! However, the product has not been evaluated in breeding, pregnant, or lactating dogs. Ive read these stories and am also disgusted. He will be laying then start shaking all over..Has tremors every 5 minutes for 2 hours now. I also reported to drug manufacturer and they are willing to reimburse me for the costs incurred. Because this ingredient works differently on invertebrates than mammals, however, Simparica for dogs has been proven safe during field trials. I am also very worried about him. I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. I am so mad at myself, he was on Heartguard + nexgard for most of his life and the vet recommended we try Simperica Trio. Vet said "cant be Simparica because he had 9 days ago". I called the breeder, and she said some vaccines and heartworm meds can cause neurological issues. Use with caution in dogs with a history of seizures or neurologic disorders. Its a horrible product and our puppy experienced a horrible reaction that eventually in a very short time took a young vibrant active very intelligent pups life in a horrible way - our Frazier would have turned 8 this past Memorial Day and we miss him everyday, I should have clarified Frazier was walking in circles because the siezures blinded him - our other puppy Watson has since only used next guard and heart guard without any further incidents but along with us showed signs of compassion during Fraziers last days and grief towards the loss of his brother Frazier. Our boy Axel had been on Heartgard his entire life. This happened the same to my dog.. how si going now with your pet? Yes Im in the same boat steroids have helped but I want to step him off of them they want him in them long term as they say this is for sure meningitis I just dont agree. She had the tablet on the Thursday and by Friday she had two very servere seizures, she is nearly three and never seen a vet before only for vaccines. We just gave the first does to our 11 week old Sheepadoodle puppy yesterday. He wasnt throwing up at all until he received this medication. Im convinced it was caused by this drug. I thought the first one it happened to may have gotten something in her eye but then a few days later the other had the same issue. for flea and ticks? If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. He has no appetite, wont drink water and his mouth is so dry. I understand them charging for the Euthanasia and cremation but they said they would keep her for 12 hours and she was put down at around 3:00 which was 1/2 the time they agreed on.Now he will get none of the fees back that the company offered for the dogs care, and hey don't have their dog .On top of that they have 3,500.00 vet bills.Why are vets allowed to charge so much?it is more than a person.It really seems as though they don't care about the pets or the people that own them Also why is these types of flea meds still on the market and why is there no legal action available for the poor consumers.I feel like they were legally assaulted by all involved and let us not forget the poor 2 year old rescue dog who ended up having a terrible short life.How unfair. Himself, tremors started again happened so again we took him to better. Couple of weeks ears started twitching not been evaluated in breeding, pregnant, why. 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