You can visit the electronic Medicines Compendium (eMC) for more detailed information about your treatment. Your nurse will tell you when your treatment is likely to be ready. I got AF again so he stopped that. This treatment can cause changes to the lungs. But it has subsided. I love to be active so I will try to stay out of bed as much as possible. I was on it in the winter and was often shocked at what would set it off in the house which was warm. 1. Talk to your doctor before starting treatment if you think you may want to have a baby in the future. Your hospital team may give you anti-diarrhoea drugs to take at home. Based on the gene mutation profile, the patient received the bevacizumab-oxaliplatin regime and then the bevacizumab-capecitabine as maintenance treatment. A blood clot is serious, but it can be treated with drugs that thin the blood (anticoagulants). Coping with cancer can be difficult. You take capecitabine tablets twice a day about 12 hours apart. Also spoil yourself a bit. Introduction & Objective: The combination of oxaliplatin and capecitabine has demonstrated its effect against various gastrointestinal cancers. Help to Overcome Problems Effectively. Capecitabine is FDA-approved as first-line treatment of patients with metastatic colorectal carcinoma when treatment with 5-FU therapy alone is preferred. tell your nurse or doctor they can give you a mouthwash or medicines to help. If your white blood cell count is low, your doctor may delay your treatment for a short time, until your cell count increases. Oxaliplatin is normally given together with other drugs to treat pancreatic cancer. Xeloda is the pill form of 5-FU and you take the pills twice a day for a week. Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). Lippincott, Williams and Wilkins, 2012. Search our clinical trials database for all cancer trials and studies recruiting in the UK, Questions about cancer? This includes vitamins, herbal supplements and over the counter remedies. A sudden feeling of cold with shivering often with a rise in temperature and sweating. It is just that there are so many unknowns, it gets frustrating. If you have diarrhoea or an increase in stoma activity: Your doctor may ask you to stop taking capecitabine. Doctors usually recommend that people with cancer have a flu vaccination and a coronavirus (covid) vaccination. Make sure you drink plenty of fluids during the 24 hours following chemotherapy. Mine will last for 6 months in 12 sessions. Try to take gentle exercise, such as walking. Taste changesusually get better after treatment finishes. Babies have the live rotavirus vaccine. Oxaliplatin and capecitabineside effects, tinnitus, has anyone else suffered with this as I'm thinking of cutting out the Oxaliplatin for the last 2 sessions to save my hearing or am I being over causious, many thanks. I guess in life I always try to hope for the best and prepare for the worst. The skin may also begin to peel. Your cancer doctor or GP can tell you more about live and inactivated vaccinations. The tube stays in place throughout the course of treatment. 5528 Background: Advanced mEOC responds poorly to standard therapy. We enrolled 663 patients (331 in nCT arm; 332 in nCRT arm) meeting inclusion criteria. The oncologist wasn't convinced the AF was caused by chemo so when I had lung mets surgically removed in 2016 he prescribedcapecitabine as a mop- up treatment. This treatment may make your eyes feel sore, red and itchy (conjunctivitis). Always tell your doctor or nurse about any skin changes. This treatment may cause hearing changes, including hearing loss. The main problems I've had was the Peripheral Neuropathy which started near the end of my treatment. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. This is called a platelet transfusion. Patients in both groups received adjuvant chemotherapy (capecitabine or fluorouracil and oxaliplatin) after CRT. Do not take another dose. Very rarely, capecitabine may cause a more serious skin condition. Tell your treatment teamif you have this. I need to head out very shortly, and will try to write more later this evening. Tell your doctor if you notice any changes in your hearing. Avoiding fatty or fried foods, eating small meals and snacks, drinking plenty of water, and relaxation techniquescan allhelp. Before starting treatment with capecitabine you have a blood test to check levels of an enzyme called dihydropyrimidine dehydrogenase (DPD). Nausea is rotten . You'llneed to have some warm or hot drinks handy if you get the throat reaction. A number of large-scale clinical trials have demonstrated that using a combination of oxaliplatin and fluoropyrimidines as an adjuvant chemotherapy for stage II/III colon cancer improved the prognosis. I am in generally good health, no medicines, conditions etc, other than this cancer thing. This is called hand-foot syndrome or palmar plantar syndrome. When the diarrhoea is better, they will tell you if you can start taking it again. There is help and support available. This treatment can cause your blood sugar and sodium levels to go up. Where I live gets really cold in the winter and when I leave the cancer center after the iv if it's really cold I have to cover my nose and mouth to breath when I'm outside, but that usually only lasts a day or two. On the other hand, if you tend to stress and trying to address it can help reduce stress by at least tryinggo for it. You take capecitabine tablets from the evening of day 1 to the morning of day 15. She still had a brilliant outcome from treatment . If you get a high temperature, let your health care teamknow straight away. I also have been left with painful feet which I did mention but not until after all my chemo had finished! You may have symptoms such as: Tell your doctor or nurse if you have these symptoms. i found that even though I received the same drugs each time, every session was different. Oxaliplatin is a diaminocyclohexane (DACH)-platinum compound that is active in several solid tu-mor types and synergistic effects have been observed when it is combined with gemcitabine, 5-FU, or capecitabine.11-13 Oxaliplatin has been studied in combination with gemcitabine (GemOx) in 2 large randomized trials and, although neither demon- So far as is permitted by law, Macmillan does not accept liability in relation to the use of any information contained in this publication or third party information or websites included or referred to in it. Your doctor will prescribe eye drops to help prevent this. a short thin tube the nurse puts into a vein in your arm or hand (, a fine tube that goes under the skin of your chest and into a vein close by (, a fine tube that is put into a vein in your arm and goes up into a vein in your chest (. For colorectal cancer: If you have breathing difficulties, take long, deep breaths through your nose. This is called palmar-plantar or hand-foot syndrome. As the others stated, getting out of bed and doing, certainly helps you past the mental/emotional aspects of doing chemo. They include: We have more information about side effects and tips on how to cope with them. This usually goes back to normal when your treatment finishes. If you are very anaemic, you may need a drip to give you extra red blood cells. I hope it's the same for you! These side effects happen in between 1 and 10 out of every 100 people (between 1 and 10%). If you have sex during a course of this treatment, you should use barrier protection such as a condom or dental dam. Oxaliplatin can make you more sensitive to the cold. God bless you on this journey. Find out about the emotional, physical and practical effects of cancer and how to manage them. Macmillan Cancer Support 2020 Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). Good luck with the rest of your treatment. Your nurse will give you advice about managing your side effects. This treatment may affect the nerves, which can cause numb, tingling or painful hands or feet. I had it surgically removed on March 22. Arm C received 3 cycles of neoadjuvant SOX and 5 cycles of adjuvant SOX . Everyone here has provided really good advice for you I just add to be flexible if you feel like crap take a nice nap, if you feel goodish then go for a walk, you'll just need to accept how you're feeling that day (hour, minute) and go with it I used to get very frustrated when I felt terrible but that got me no where. Tell your doctor if you have these symptoms. Can't change anything now. About Cancer generously supported by Dangoor Education since 2010. 2011 Jun;9(6):492-500. Feeling or being sickis usually well controlled with anti sickness medicines. Diarrhoea means passing more stools (poo) than is usual for you, or having watery or loose stools. 52.8% of patients accomplished full dose of adjuvant chemotherapy in nCT arm compared to 44.1% in nCRT arm (P= 0.065). Oxaliplatin, an antineoplastic, platinum-based anticancer drug, undergoes nonenzymatic conversion to active derivatives that form crosslinks within the DNA molecule. This means you have the drugs and then a rest to allow your body to recover. Contact the hospital straight away on the 24-hour contact number you have been given if: It is important to follow any specific advice your cancer treatment team gives you. Before starting this treatment, you should have a blood test to check whether you have low levels of an enzyme called DPD. LOL. Wear good fitting shoes and socks to prevent rubbing. follow any advice from your hospital team about taking anti-diarrhoea drugs, drink at least 2 litres (3 pints) of fluids each day. Drink plenty of fluids and eat as much fresh fruit and vegetables as you can. Your nurse usually gives you anti-sickness (anti-emetic) drugs before the chemotherapy. You may get pain or discomfort in your tummy (abdomen). This treatment may also cause blurry vision. Its a horrible condition . The drugs may harm a developing baby. The side affects suck, but I'm doing much better on these drugs than I was when I was first diagnosed, so for me it's worth it. Hi: I found out I had a tumor in my upper colon on February 7, 2017. You'll need them for taking things out of the fridge or doing things like making dinner if you're cutting up vegetables, things like that. XELOX (or CAPOX) is used to treat bowel cancer. For further information about this treatment go to the electronic Medicines Compendium (eMC)website. During treatment, and for a few days afterwards, it may help to: It is important to tell your doctor if you have this side effect. I was good for over a year and now I have two mets in one lung so I'm on Xeloda for that. CAPOX (oxaliplatin & capecitabine) CRP09 CR008-v1.5 Page 5 of 5 Issue Date 28.02.18 Expiry Date: 01.03.2021 Table of dose adjustments according to CTC toxicity (Not PPE/hand/foot syndrome) Grade 2 Grade 3 Grade 4 1st appearance Interrupt treatment until resolved to grade 0/1, then . Just try to not think too long about it. Very rarely, this can cause heart failure or a heart attack. Worth having a chat . Mouth sores and ulcerscan be painful. If you have a stoma, it will be more active than usual. You may get some of the side effects we mention, but you are unlikely to get all of them. This will protect your partner if any of the drug is in your semen or vaginal fluid. You may also feel unwell with flu-like symptoms such as a high temperature and joint pain. This can be a: You mighthave treatmentthrough a thin short tube (a cannula) that goes into a vein in your arm. It comprises < 8% pts in ovarian cancer trials, so it is difficult to examine treatment effects in this subgroup. You may get sore and red palms of hands and soles of feet. Aims: To determine the efficacy of the combination of oxaliplatin and capecitabine in patients with advanced colorectal cancer. Don't push yourself, rest when you start to feel tired and ask others for help. Save these numbers in your phone or keep them somewhere safe. Use a soft toothbrush to clean your teeth or dentures in the morning, at night and after meals. Arms A and B respectively received 8 cycles of adjuvant XELOX (capecitabine 1000 mg/m 2, bid, d1-14, oxaliplatin 130 mg/m 2, d1, q3W) or SOX (TS-1: 40-60 mg bid, d1-14, oxaliplatin: 130 mg/m 2 d1, q3W). I had rash on my neck due to tape for the catheter that runs through jugular/collarbone. If your immune system is weak, you need to avoid live vaccinations. court over 3 years ago. I had chemo on Monday, took the next 2 days off and then worked for the next 2 weeks with no problem. Treatment was given over a 21-day cycle with a fixed dosing of intravenous oxaliplatin of 130 mg/m(2) on day 1. No matter how bad I felt- and believe me, I felt bad - I always got out of bed. You might have two different strengths of tablets to make up the correct dose. Always tell your cancer doctor about any drugs you are taking or planning to take, such as: Tell other doctors, pharmacists or dentists who prescribe or give you medicines that you are having this cancer treatment. Tell your doctor or nurse if you are finding it difficult to control your weight. The lab work showed I had Stage 3 cancer with 3 of 27 lymph nodes affected. This is calledanaemia. Capecitabine and oxaliplatin concomitantly with radiation therapy has been evaluated before surgery in rectal cancer treatment. At the end of the rest period, you start your second cycle of XELOX. It helps by slowing the growth of blood vessels to provide food for the tumors. Tell your healthcare team if you're finding it difficult to walk or complete fiddly tasks such as doing up buttons. sharp chest pain, which may be worse when you cough or take a deep breath. Stage 4 means that the cancer has spread to one or more other organs. If the number of red blood cells is low, this is called anaemia. Tell your doctor or nurse if you keep gettingheadaches. You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme. This is called DPD deficiency. Abstract. Let your nurse know straight away if your drip site is causing you pain. No stomach cramps or anything like that. Great! There will be times where you wonder how could this happen and all the rest. Roland KKeel Thanks for the comments. You can talk to your cancer doctor about your risk of having DPD deficiency before you start treatment. You have oxaliplatin and capecitabine chemotherapy as cycles of treatment. Join our free cancer forums and chat anonymously to others who understand what you are going through. Rather than completely stopping it you might want to chat to your oncologist about a reduction in strength . Rarely, oxaliplatin can affect the nervous system. the anti-diarrhoea drugs do not work within 24 hours. I usually feel a bit off (mostly low energy) for a week - week and a half, then I feel good for a week and a half - two weeks. And would sleep close to 40 out of 48 hours. Thats a very annoying side effect. Both went away after a few days. INTRODUCTION; REGIMENS. You may have ringing in the ears. Electronic Medicines Compendium You may also become unable to hear some high-pitched sounds. This means they will be more likely to work for you. You might have one or more of them. His Drs says theres no standard line second-line treatment . This can make you more likely to get a mouth or throat infection. 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